Over many years researchers have identified the link between bipolar disorder and stress. This link has also been confirmed by tests done on the connection between child abuse and bipolar [cited in a separate article in this blog]. One researcher has identified the significant role of extreme anxiety in the initiation of manic episodes. This researcher also found there is a link between stress abuse and the hypothalamic-pituitary axis. In other words severe stress can detrimentally impact upon endocrine systems and associated hormonal activity. I have observed the life experiences of one person who’s life time medical condition seems to have been impacted upon this way, including with tumors. I feel some readers may not appreciate this connection.

https://www.frontiersin.org/articles/10.3389/fpsyt.2014.00098/full